Mitigating GI risks associated with the use of NSAIDs.

OBJECTIVE Nonsteroidal anti-inflammatory drugs (NSAIDs) have multiple established adverse effects on various organ systems. Among those associated with high mortality are gastrointestinal complications. We address the scope of the problem and the scientific basis for risk mitigation. DESIGN This review covers the most successful of such strategies published to date. RESULTS Mitigation strategies to enable ongoing anti-inflammatory benefit are well studied, albeit imperfect. CONCLUSIONS Such strategies may involve the choice of NSAID or the combined use of gastroprotective measures in association with NSAIDs.